Table 3 Levels of oxylipins that were significantly altered by prometryn in plasma of mice.

From: Triazine herbicide prometryn alters epoxide hydrolase activity and increases cytochrome P450 metabolites in murine livers via lipidomic profiling

Oxylipin

Control (n = 8)

Prometryn (n = 11)

p-value

Epoxides

 8(9)-EpETrE

304.53 ± 285.84

58.90 ± 51.90

< 0.05

 9(10)-EpODE

1016.81 ± 649.32

382.99 ± 371.97

< 0.05

 12(13)-EpODE

120.59 ± 86.09

47.57 ± 53.31

< 0.05

 15(16)-EpODE

3177.93 ± 2557.68

1136.46 ± 1521.93

< 0.05

 8(9)-EpETE

102.88 ± 62.89

36.52 ± 34.23

< 0.05

 11(12)-EpETE

54.44 ± 34.54

19.53 ± 20.46

< 0.05

 14(15)-EpETE

52.05 ± 33.63

17.90 ± 18.31

< 0.05

 17(18)-EpETE

92.70 ± 64.40

28.77 ± 27.10

< 0.05

 7(8)-EpDPE

8146.75 ± 7102.16

1132.57 ± 1106.06

< 0.05

Trihydroxy fatty acids

 9,10,13-TriHOME

3233.00 ± 1848.24

1569.55 ± 677.68

< 0.05

  1. Results are in nmol/L, mean ± standard deviation (mean ± SD). Significance level for the comparison between control and prometryn treated groups using the procedures described in the methods section. The metabolites are arranged in each section by chain length, then double bond so that LA, ALA, AA, EPA, and DHA metabolites (if present) are separated.
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