Table 2 Marginal means of NMR-based metabolic biomarkers in osteoporosis patients with and without incident fracture, divided by gender.
From: Lipid metabolites are associated with the risk of osteoporotic fractures
Male | Female | |||||
|---|---|---|---|---|---|---|
Osteoporosis without fracture N = 840 | Osteoporosis with fracture N = 138 | p value | Osteoporosis without fracture N = 4188 | Osteoporosis with fracture N = 327 | p value | |
Free Cholesterol in HDL | 0.25 (0.22, 0.30) | 0.25 (0.23, 0.30) | 0.576 | 0.32 (0.27, 0.37) | 0.32 (0.28, 0.38) | 0.149 |
Total Lipids in HDL | 2.69 (2.36, 3.12) | 2.67 (2.41, 3.12) | 0.510 | 3.23 (2.83, 3.66) | 3.22 (2.86, 3.81) | 0.199 |
Total Cholines | 2.34 (2.06, 2.60) | 2.38 (2.15, 2.65) | 0.185 | 2.68 (2.43, 2.93) | 2.69 (2.44, 2.98) | 0.469 |
Sphingomyelins | 0.41 (0.36, 0.45) | 0.41(0.37, 0.46) | 0.238 | 0.47 (0.42, 0.52) | 0.47 (0.43, 0.52) | 0.270 |
Degree of Unsaturation | 1.33 (1.28, 1.39) | 1.32 (1.27, 1.37) | 0.118 | 1.39 (1.34, 1.44) | 1.38 (1.33, 1.43) | 0.280 |
Polyunsaturated Fatty Acids to Total Fatty Acids percentage | 42.27 (38.86, 44.64) | 41.32 (38.19, 44.05) | 0.142 | 43.59 (41.17, 45.55) | 43.29 (41.07, 45.23) | 0.138 |
Histidine | 0.06 (0.06, 0.07) | 0.06 (0.06, 0.07) | 0.400 | 0.06 (0.06, 0.07) | 0.06 (0.06, 0.07) | 0.114 |
3-Hydroxybutyrate | 0.04 (0.03, 0.07) | 0.05 (0.03, 0.08) | 0.598 | 0.04 (0.03, 0.08) | 0.05 (0.03, 0.09) | 0.001 |
Acetone | 0.01 (0.01, 0.02) | 0.01 (0.01, 0.02) | 0.408 | 0.01 (0.01, 0.02) | 0.01 (0.01, 0.02) | 0.003 |
Total Lipids in Medium HDL | 0.93 (0.81, 1.08) | 0.94 (0.82, 1.08) | 0.352 | 1.10 (0.96, 1.24) | 1.10 (0.97, 1.27) | 0.268 |
Phospholipids in Medium HDL | 0.44 (0.39, 0.51) | 0.45 (0.40, 0.51) | 0.293 | 0.51 (0.45, 0.58) | 0.51 (0.458, 0.60) | 0.273 |
Cholesteryl Esters in Large HDL | 0.17 (0.11, 0.26) | 0.16 (0.12, 0.24) | 0.844 | 0.27 (0.19, 0.38) | 0.28 (0.18, 0.39) | 0.273 |
Triglycerides in Small LDL | 0.01 (0.01, 0.02) | 0.01 (0.01, 0.02) | 0.470 | 0.01 (0.01, 0.02) | 0.01 (0.01, 0.02) | 0.558 |
Phospholipids in Very Large HDL | 0.06 (0.04, 0.09) | 0.06 (0.05, 0.08) | 0.604 | 0.09 (0.07, 0.13) | 0.09 (0.07, 0.13) | 0.476 |
Concentration of Large HDL Particles | 0.00 (0.00, 0.00) | 0.00 (0.00, 0.00) | 0.970 | 0.00 (0.00, 0.00) | 0.00 (0.00, 0.00) | 0.248 |
