Figure 2

RNA affinity pulldown and mass spectrometry identify novel binding partners of lncTCF7. (A) Schematic of biotinylated RNA-pulldown and mass spectrometry method. (B) The enriched proteins, ordered based on log 2 rank ratio. (C) The top enriched proteins in HOTAIR D1 pulldown identify two previously studied HOTAIR functional partners, HNRNP A2/B1 and HuR. (D) Proteins similarly enriched in both lncTCF7 and HOTAIR D1 pulldowns. (E) The top five proteins enriched in the full-length lncTCF7 pulldown (data averaged of two replicates).