Table 1 Correlation analysis between GARS1 and markers of immune cells in BLCA patients in TIMER2 and GEPIA2.

From: Multiple omics integrative analysis identifies GARS1 as a novel prognostic and immunological biomarker: from pan-cancer to bladder cancer

Cell type

Gene marker

None

Cor

p

Purity

Cor

p

Tumor

R

p

Normal

R

p

B cell

CD19

0.118

*

0.01

0.85

− 0.025

0.62

0.48

*

CD20 (KRT20)

− 0.137

**

− 0.061

0.246

− 0.055

0.27

0.21

0.4

CD38

0.318

***

0.213

***

0.062

0.21

0.42

0.073

CD8+ T cell

CD8A

0.233

***

0.108

*

0.096

0.055

0.21

0.38

CD8B

0.192

***

0.11

*

0.41

*

0.28

0.25

Tfh

BCL6

− 0.22

***

− 0.195

***

− 0.16

**

− 0.36

0.13

ICOS

0.252

***

0.124

*

0.077

0.12

0.53

*

CXCR5

0.09

0.0708

− 0.07

0.183

0.1

*

0.45

0.056

Th1

T-bet (TBX21)

0.199

***

0.064

0.22

0.08

0.11

0.36

0.13

STAT4

0.213

***

0.081

0.119

0.076

0.13

0.27

0.27

IL12RB2

0.369

***

0.305

***

0.079

0.11

0.31

0.2

WSX1 (IL27RA)

0.357

***

0.302

***

0.17

***

0.46

*

STAT1

0.369

***

0.293

***

0.049

0.32

− 0.051

0.84

IFN-γ (IFNG)

0.23

***

0.138

**

0.13

**

− 0.19

0.43

TNF-α (TNF)

0.225

***

0.145

**

0.11

*

0.064

0.79

Th2

GATA3

− 0.244

***

− 0.174

***

− 0.0075

0.88

− 0.16

0.52

CCR3

0.142

**

0.108

0.0386

0.1

*

0.27

0.27

STAT6

− 0.198

***

− 0.171

***

− 0.25

***

− 0.7

***

STAT5A

0

0.999

− 0.094

0.0702

− 0.089

0.075

− 0.37

0.12

Th9

TGFBR2

0.176

***

0.116

*

0.037

0.45

− 0.53

*

IRF4

0.171

***

− 0.001

0.983

− 0.015

0.77

0.36

0.13

PU.1 (SPI1)

0.259

***

0.127

*

0.17

***

0.24

0.31

Th17

STAT3

0.272

***

0.208

***

− 0.098

*

− 0.33

0.17

IL-21R

0.247

***

0.114

*

0.051

0.31

0.48

*

IL-23R

− 0.068

0.172

− 0.123

*

− 0.069

0.17

0.22

0.36

IL-17A

− 0.0029

0.553

− 0.038

0.462

− 0.0069

0.89

0.021

0.93

Th22

CCR10

− 0.059

0.236

− 0.07

0.181

0.019

0.71

0.062

0.8

AHR

− 0.033

0.51

0.015

0.774

0.073

0.14

− 0.25

0.3

Treg

FOXP3

0.255

***

0.145

**

0.084

0.093

0.51

*

CD25 (IL2RA)

0.351

***

0.264

***

0.14

**

0.21

0.39

CCR8

0.275

***

0.174

***

− 0.0069

0.89

0.4

0.093

T cell exhaustion

PD-1 (PDCD1)

0.195

***

0.053

0.313

0.065

0.19

0.44

0.061

CTLA4

0.223

***

0.084

0.106

0.15

**

0.48

*

LAG3

0.302

***

0.193

***

0.18

***

0.34

0.15

TIM-3 (HAVCR2)

0.34

***

0.235

***

0.18

***

0.14

0.58

Macrophage

CD68

0.226

***

0.13

*

0.078

0.12

0.2

0.42

CD11b (ITGAM)

0.29

***

0.19

***

0.004

0.94

− 0.15

0.55

M1

INOS (NOS2)

0.097

0.0512

0.08

0.127

− 8.80E−05

1

6.80E−02

0.78

IRF5

− 0.128

**

− 0.135

**

− 0.045

0.36

0.18

0.47

COX2 (PTGS2)

0.057

0.249

0.012

0.816

− 0.0043

0.93

− 0.19

0.44

M2

CD16

0.393

***

0.313

***

0.15

**

0.0035

0.99

ARG1

− 0.046

0.354

0.013

0.8

− 0.014

0.78

0.47

*

MRC1

0.354

***

0.277

***

0.12

*

− 0.32

0.19

MS4A4A

0.358

***

0.268

***

0.22

***

− 0.3

0.21

TAM

CCL2

0.259

***

0.143

**

0.18

**

− 0.094

0.7

CD80

0.358

***

0.271

***

0.15

**

0.34

0.16

CD86

0.342

***

0.251

***

0.2

***

0.24

0.33

CCR5

0.269

***

0.146

**

0.095

0.055

0.34

0.15

Monocyte

CD14

0.327

***

0.226

***

0.18

***

0.0061

0.98

CD16 (FCGR3B)

0.219

***

0.153

**

0.011

0.83

0.059

0.81

CD115 (CSF1R)

0.293

***

0.174

***

0.18

***

− 0.18

0.47

Neutrophil

CD66b (CEACAM8)

0.001

0.987

0.03

0.57

− 0.052

0.29

0.2

0.41

CD15 (FUT4)

0.302

***

0.248

***

0.018

0.72

− 0.32

0.18

CD11b (ITGAM)

0.29

***

0.19

***

0.004

0.94

− 0.15

0.55

Natural killer cell

XCL1

0.052

0.293

0.064

0.221

0.068

0.17

0.59

0.13

CD7

0.192

***

0.041

0.429

0.096

0.053

0.46

*

KIR3DL1

0.119

0.0162

0.037

0.48

0.019

0.71

0.55

*

Dendritic cell

CD1C (BDCA-1)

− 0.055

0.271

− 0.17

**

− 0.022

0.66

0.41

0.085

CD141 (THBD)

0.143

**

0.08

0.123

0.016

0.75

0.071

0.77

CD11c (ITGAX)

0.321

***

0.203

***

0.079

0.11

0.21

0.38

  1. BLCA bladder urothelial carcinoma, Tfh follicular helper T cell, Th T helper cell, Treg regulatory T cell, TAM tumor-associated macrophage.
  2. None, Correlation without adjustment; Purity, correlation conditioned on tumor purity; Tumor, correlation analysis in tumor tissue of TCGA; Normal, correlation analysis in normal tissue of TCGA.
  3. Cor, R value of Pearman’s correlation *p < 0.05; **p < 0.01; ***p < 0.001.