Table 1 Correlation analysis between GARS1 and markers of immune cells in BLCA patients in TIMER2 and GEPIA2.
Cell type | Gene marker | None Cor | p | Purity Cor | p | Tumor R | p | Normal R | p |
|---|---|---|---|---|---|---|---|---|---|
B cell | CD19 | 0.118 | * | 0.01 | 0.85 | − 0.025 | 0.62 | 0.48 | * |
CD20 (KRT20) | − 0.137 | ** | − 0.061 | 0.246 | − 0.055 | 0.27 | 0.21 | 0.4 | |
CD38 | 0.318 | *** | 0.213 | *** | 0.062 | 0.21 | 0.42 | 0.073 | |
CD8+ T cell | CD8A | 0.233 | *** | 0.108 | * | 0.096 | 0.055 | 0.21 | 0.38 |
CD8B | 0.192 | *** | 0.11 | * | 0.41 | * | 0.28 | 0.25 | |
Tfh | BCL6 | − 0.22 | *** | − 0.195 | *** | − 0.16 | ** | − 0.36 | 0.13 |
ICOS | 0.252 | *** | 0.124 | * | 0.077 | 0.12 | 0.53 | * | |
CXCR5 | 0.09 | 0.0708 | − 0.07 | 0.183 | 0.1 | * | 0.45 | 0.056 | |
Th1 | T-bet (TBX21) | 0.199 | *** | 0.064 | 0.22 | 0.08 | 0.11 | 0.36 | 0.13 |
STAT4 | 0.213 | *** | 0.081 | 0.119 | 0.076 | 0.13 | 0.27 | 0.27 | |
IL12RB2 | 0.369 | *** | 0.305 | *** | 0.079 | 0.11 | 0.31 | 0.2 | |
WSX1 (IL27RA) | 0.357 | *** | 0.302 | *** | 0.17 | *** | 0.46 | * | |
STAT1 | 0.369 | *** | 0.293 | *** | 0.049 | 0.32 | − 0.051 | 0.84 | |
IFN-γ (IFNG) | 0.23 | *** | 0.138 | ** | 0.13 | ** | − 0.19 | 0.43 | |
TNF-α (TNF) | 0.225 | *** | 0.145 | ** | 0.11 | * | 0.064 | 0.79 | |
Th2 | GATA3 | − 0.244 | *** | − 0.174 | *** | − 0.0075 | 0.88 | − 0.16 | 0.52 |
CCR3 | 0.142 | ** | 0.108 | 0.0386 | 0.1 | * | 0.27 | 0.27 | |
STAT6 | − 0.198 | *** | − 0.171 | *** | − 0.25 | *** | − 0.7 | *** | |
STAT5A | 0 | 0.999 | − 0.094 | 0.0702 | − 0.089 | 0.075 | − 0.37 | 0.12 | |
Th9 | TGFBR2 | 0.176 | *** | 0.116 | * | 0.037 | 0.45 | − 0.53 | * |
IRF4 | 0.171 | *** | − 0.001 | 0.983 | − 0.015 | 0.77 | 0.36 | 0.13 | |
PU.1 (SPI1) | 0.259 | *** | 0.127 | * | 0.17 | *** | 0.24 | 0.31 | |
Th17 | STAT3 | 0.272 | *** | 0.208 | *** | − 0.098 | * | − 0.33 | 0.17 |
IL-21R | 0.247 | *** | 0.114 | * | 0.051 | 0.31 | 0.48 | * | |
IL-23R | − 0.068 | 0.172 | − 0.123 | * | − 0.069 | 0.17 | 0.22 | 0.36 | |
IL-17A | − 0.0029 | 0.553 | − 0.038 | 0.462 | − 0.0069 | 0.89 | 0.021 | 0.93 | |
Th22 | CCR10 | − 0.059 | 0.236 | − 0.07 | 0.181 | 0.019 | 0.71 | 0.062 | 0.8 |
AHR | − 0.033 | 0.51 | 0.015 | 0.774 | 0.073 | 0.14 | − 0.25 | 0.3 | |
Treg | FOXP3 | 0.255 | *** | 0.145 | ** | 0.084 | 0.093 | 0.51 | * |
CD25 (IL2RA) | 0.351 | *** | 0.264 | *** | 0.14 | ** | 0.21 | 0.39 | |
CCR8 | 0.275 | *** | 0.174 | *** | − 0.0069 | 0.89 | 0.4 | 0.093 | |
T cell exhaustion | PD-1 (PDCD1) | 0.195 | *** | 0.053 | 0.313 | 0.065 | 0.19 | 0.44 | 0.061 |
CTLA4 | 0.223 | *** | 0.084 | 0.106 | 0.15 | ** | 0.48 | * | |
LAG3 | 0.302 | *** | 0.193 | *** | 0.18 | *** | 0.34 | 0.15 | |
TIM-3 (HAVCR2) | 0.34 | *** | 0.235 | *** | 0.18 | *** | 0.14 | 0.58 | |
Macrophage | CD68 | 0.226 | *** | 0.13 | * | 0.078 | 0.12 | 0.2 | 0.42 |
CD11b (ITGAM) | 0.29 | *** | 0.19 | *** | 0.004 | 0.94 | − 0.15 | 0.55 | |
M1 | INOS (NOS2) | 0.097 | 0.0512 | 0.08 | 0.127 | − 8.80E−05 | 1 | 6.80E−02 | 0.78 |
IRF5 | − 0.128 | ** | − 0.135 | ** | − 0.045 | 0.36 | 0.18 | 0.47 | |
COX2 (PTGS2) | 0.057 | 0.249 | 0.012 | 0.816 | − 0.0043 | 0.93 | − 0.19 | 0.44 | |
M2 | CD16 | 0.393 | *** | 0.313 | *** | 0.15 | ** | 0.0035 | 0.99 |
ARG1 | − 0.046 | 0.354 | 0.013 | 0.8 | − 0.014 | 0.78 | 0.47 | * | |
MRC1 | 0.354 | *** | 0.277 | *** | 0.12 | * | − 0.32 | 0.19 | |
MS4A4A | 0.358 | *** | 0.268 | *** | 0.22 | *** | − 0.3 | 0.21 | |
TAM | CCL2 | 0.259 | *** | 0.143 | ** | 0.18 | ** | − 0.094 | 0.7 |
CD80 | 0.358 | *** | 0.271 | *** | 0.15 | ** | 0.34 | 0.16 | |
CD86 | 0.342 | *** | 0.251 | *** | 0.2 | *** | 0.24 | 0.33 | |
CCR5 | 0.269 | *** | 0.146 | ** | 0.095 | 0.055 | 0.34 | 0.15 | |
Monocyte | CD14 | 0.327 | *** | 0.226 | *** | 0.18 | *** | 0.0061 | 0.98 |
CD16 (FCGR3B) | 0.219 | *** | 0.153 | ** | 0.011 | 0.83 | 0.059 | 0.81 | |
CD115 (CSF1R) | 0.293 | *** | 0.174 | *** | 0.18 | *** | − 0.18 | 0.47 | |
Neutrophil | CD66b (CEACAM8) | 0.001 | 0.987 | 0.03 | 0.57 | − 0.052 | 0.29 | 0.2 | 0.41 |
CD15 (FUT4) | 0.302 | *** | 0.248 | *** | 0.018 | 0.72 | − 0.32 | 0.18 | |
CD11b (ITGAM) | 0.29 | *** | 0.19 | *** | 0.004 | 0.94 | − 0.15 | 0.55 | |
Natural killer cell | XCL1 | 0.052 | 0.293 | 0.064 | 0.221 | 0.068 | 0.17 | 0.59 | 0.13 |
CD7 | 0.192 | *** | 0.041 | 0.429 | 0.096 | 0.053 | 0.46 | * | |
KIR3DL1 | 0.119 | 0.0162 | 0.037 | 0.48 | 0.019 | 0.71 | 0.55 | * | |
Dendritic cell | CD1C (BDCA-1) | − 0.055 | 0.271 | − 0.17 | ** | − 0.022 | 0.66 | 0.41 | 0.085 |
CD141 (THBD) | 0.143 | ** | 0.08 | 0.123 | 0.016 | 0.75 | 0.071 | 0.77 | |
CD11c (ITGAX) | 0.321 | *** | 0.203 | *** | 0.079 | 0.11 | 0.21 | 0.38 |