Figure 3

Schematic representation of the main findings of the study. Six-months exposure to DnHP impairs endocannabinoid signaling by upregulating both cannabinoid receptors while the combined administration of DnHP and Lpb. plantarum probiotic strain IMC513 reverses the ECS modulation. Graphical illustrations were created by using some graphical elements from Servier Medical Art by Servier, available on https://smart.servier.com/ under a Creative Commons Attribution 3.0 Unported License.