Table 4 Diagnostic sensitivity of the five urinary metabolic markers of TBM at specified cut-off concentrations.
Metabolite | Diagnostic criteria | Mild TBM | Severe TBM |
|---|---|---|---|
1-Methylnicotinamide | Conc (mmol/mol cr) | > 14 | > 14.45 |
Sensitivity % | 100 (67.6–100) | 91.3 (73–98.5) | |
3-Hydroxyisovaleric acid | Conc (mmol/mol cr) | > 27.33 | > 27.41 |
Sensitivity % | 75 (41–95.6) | 95.7 (79–100) | |
5-Aminolevulinic acid | Conc (mmol/mol cr) | > 47.89 | > 47.84 |
Sensitivity % | 87.5 (53–99) | 87 (68–95.5) | |
N-Acetylglutamine | Conc (mmol/mol cr) | > 117.3 | > 127.5 |
Sensitivity % | 100 (67.6–100) | 95.7 (79–100) | |
Methanol | Conc (mmol/mol cr) | > 29.46 | > 29.86 |
Sensitivity % | 62.5 (30.5–95.6) | 73.9 (53.5–87.5) |
