Fig. 2
From: Multiple endocrine defects in adult-onset Sprouty1/2/4 triple knockout mice
Phenotypic changes of 3KO mice. (a) Unlike WT animals, 3KO mice do not gain weight over time. (b) Weight analysis in WT and 3KO animals by gender at 7 and 12 months of age. (c) Representative pictures of male and female WT and 3KO animals at 12 months of age. In the lower panel, the abdominal cavity is shown, revealing significant differences in visceral fat depots between WT and 3KO animals, both in males and females. (d) Water and food intake, as well as urine volume, are not different between WT and 3KO mice. (e) Plasma glucose and T4 levels of WT and 3KO animals at six months of age. (f) Representative pictures of WT and 3KO mice showing facial abnormalities including alopecia and enlarged eyelids. (g) Incidence of alopecia in 3KO mice by gender at 7 months of age. Graphs (b,d,e) represent means ± SD; significance (ns P > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001) was determined using two-way ANOVA (b,e) and t test (d). Graph (f) represent phenotype incidences; significance (ns P > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001) was determined using Fisher’s exact test.
