Fig. 3
From: Multiple endocrine defects in adult-onset Sprouty1/2/4 triple knockout mice
Motor activity deficiencies in 3KO mice. (a) Open-field analysis shows anxiety-like behavior and motor abnormalities in 3KO mice. In the upper left panel a schematic Open-field arena is represented, differentiating central and edge squares. The two following panels show entries to the inner zone (%center), and total entered squares. Bottom three panels show motor performance measured as the average and maximum velocity (cm/s) and distance covered (cm). (b) Coat-hanger test reveals reduced strength and coordination of 3KO mice. In the left panel, the scoring scheme for animal movement is depicted. In the following two panels, the test results are presented, categorized by genotype, with reference to latency time and movement score. Graphs (a) and (b, center panel) represent means ± SD; significance (ns P > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001) was determined using two-way ANOVA. Graph (b, right panel) represents score frequencies; significance (ns P > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001) was determined using Fisher’s exact test.
