Table 2 Significant orthogroups identified by Boruta in clinical categories comparison. The table displays the relevant orthogroups identified by Boruta to distinguish PBC-associated compared to LI-associated genomes, and LS-associated compared to BAC-associated genomes. For each orthogroup, the gene name, whether available, the gene product, the mean length and standard deviation of the predicted protein, and the prevalence of the orthogroup in the genomes of the clinical categories are reported. The p-values of the Chi-squared test used to evaluate the distribution of orthogroups according to the clinical categories are displayed.

From: Association of pathogenic determinants of Fusobacterium necrophorum with bacteremia, and Lemierre’s syndrome

Orthogroup (PBC vs. LI)

Gene name

Gene product

Protein mean length (sd)

Prevalence/PBC genomes

Prevalence/LI genomes

p-value

group_13

DUF1353 domain-containing protein

149.5 (0.9)

9/19

40/51

0.026

group_1948

cas8a1

Type I CRISPR-associated protein Cas8a1/Csx8

414.8 (96.5)

15/19

20/51

0.007

group_1955

ftsY

Signal recognition particle-docking protein FtsY

77.1 (5.8)

2/19

26/51

0.005

group_2124

T2SP-E domain-containing protein

126

5/19

19/51

0.566

group_2260

Sodium:solute symporter

490

8/19

7/51

0.025

group_2788

Hypotethical protein

93

4/19

0/51

0.005

Orthogroup (LS vs. BAC)

Gene name

Gene product

Mean length (sd)

Prevalence/LS genomes

Prevalence/BAC genomes

p-value

group_1749

POP1 domain-containing protein

407.9 (122.1)

11/11

4/8

0.038