Fig. 4
From: MYH6 suppresses tumor progression by downregulating KIT expression in human prostate cancer
MYH6 suppresses prostate cancer cell proliferation and migration by repressing KIT expression. (A) Volcano plot for DEGs in MYH6-overexpressing DU145 RNA-seq. (B) The GO enrichment terms of DEGs. (C) KEGG pathway analysis of DEGs. (D) RT-qPCR analyses of the mRNA levels and western blotting analysis of protein levels of the KIT gene in prostate cancer cells with a control vector or MYH6 overexpression. (E) Representative immunohistochemistry of MYH6 and KIT on benign prostate and prostate cancer tissues. (F) KIT overexpression rescued the MYH6-mediated decrease in cell proliferation in DU145 cells. One-way ANOVA was used. (G) KIT overexpression rescued MYH6-mediated defects in cell migration (**P < 0.01, ***P < 0.001).
