Fig. 3
MR analysis results for thyroid preparation use and its impact on PD risk. (A) Scatter plot illustrating potential effects of SNPs on Thyroid preparation use and PD risk using IVW, MR-Egger, and weighted median methods. The slope of fitted lines represents the estimated MR effect per method. At the same time, the 95% confidence interval (CI) for the impact of size on thyroid preparation use and PD risk is shown as vertical and horizontal lines, respectively. (B) Funnel plot for thyroid preparation use, showing estimation using the inverse of the standard error of causal estimate with each SNP as a tool. The vertical line depicts the estimated causal effect obtained using IVW and MR-Egger methods. (C) Forest plot demonstrating the impact of each SNP in the MR analysis. (D) Forest plot presenting the leave-one-out sensitivity analysis results, where each SNP in the instrument is iteratively removed to check the result’s stability.
