Table 2 Association results of detected risk variants.

From: Identification of genetic variants associated with clinical features of sickle cell disease

Trait

Locus

Gene

SNP

EA/NEA

BETAdis

Pdis

BETArep

Prep

BETAall

Pall

Pcorrect

HbF

2p16.1

BCL11A

rs1427407

T/G

4.28

6.06E−04

4.08

9.55E−07

4.14

8.58E−10

8.84E−10

rs766432

C/A

3.32

3.88E−03

4.11

9.06E−07

3.83

6.72E−09

6.92E−09

15q14

EMC7

rs8182015

C/G

7.23

1.46E−04

5.11

6.02E−05

5.80

2.07E−08

2.13E−08

Acute chest syndrome

15q26.1

IDH2

rs79915189

C/G

0.43

2.36E−04

0.25

3.02E−05

0.28

3.70E−08

3.85E−08

Pain

2p25.1

ASAP2

rs62118798

A/G

0.81

4.90E−03

0.58

3.35E−06

0.62

3.99E−08

4.19E−08

5q35.1

SLIT3

rs71605708

C/T

0.31

0.12

0.56

1.62E−07

0.51

4.28E−08

4.49E−08

15q26.1

ZNF710

rs62020555

C/T

2.45

9.31E−05

2.31

3.76E−06

2.37

4.64E−10

4.87E−10

15q26.3

LRRK1

rs117797325

T/C

2.66

1.83E−02

1.95

4.95E−07

2.03

1.78E−08

1.87E−08

Vaso-occlusive episodes

2p25.1

ASAP2

rs62118798

A/G

0.81

4.83E−03

0.56

3.47E−06

0.60

4.27E−08

4.48E−08

15q26.1

ZNF710

rs62020555

C/T

2.46

7.91E−05

2.09

1.67E−05

2.23

2.04E−09

2.14E−09

15q26.3

LRRK1

rs117797325

T/C

2.66

1.74E−02

1.83

1.18E−06

1.91

4.63E−08

4.86E−08

Admission

17q21.31

ETV4

rs76714145

A/G

2.24

4.59E−04

1.43

9.72E−06

1.60

1.59E−08

1.64E−08

  1. SNP single nucleotide polymorphism, EA effect allele, NEA non-effect allele.
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