Fig. 5
From: SIRT1 silencing ameliorates malignancy of non-small cell lung cancer via activating FOXO1
SIRT1 deletion restrains the malignant phenotypes of NSCLC cells via FOXO pathway. (A) The expression levels of FOXO1 in H1299 cells after SIRT1 interference and subsequent AS1842856 treatment were checked by qRT-PCR. (B) The viability of H1299 cells after different treatment was measured by CCK-8. (C) EDU assay for the assessment of the cell proliferation in H1299 cells after different treatment. (D) The apoptosis of NSCLC cells in each group was assessed through flow cytometry. (E) The migration of NSCLC cells in each group was measured using the wound healing assay. Scale bar: 100 μm. (F) The invasion ability of NSCLC cells stably in each group was detected by transwell assay. Scale bar: 100 μm. **p < 0.01 vs. si-NC; ##p < 0.01 vs. si-SIRT1.
