Fig. 6
From: Inhibition of miR-194-5p avoids DUSP9 downregulation thus limiting sepsis-induced cardiomyopathy
DUSP9 inhibition abolished the favorable effects of miR-194-5p antagomir on cardiac function and inflammation in sepsis-challenged mice. (a–d) Representative immunoblots for DUSP9, p-p38, p-38, p-JNK, JNK and GAPDH in the heart tissue from the respective groups (n = 4). (e) Representative echocardiographic images are shown (n = 20). (f) Left ventricular end-diastolic diameter (LVEDD). (g) Left ventricular end-systolic diameter (LVESD). (h) Left ventricular ejection fraction (LVEF). (i) Left ventricular fraction shortening (LVFS). (j) and (k) First derivative of the left ventricular pressure (± LV dp/dt max) (n = 4). (l–n) Levels of IL-1β, IL-6, and TNF-α in heart tissue were measured (n = 5). *P < 0.05 LPS + shCtrl, #P < 0.05 versus LPS + shDUSP9, $P < 0.05 versus LPS + miR-194-5p antagomir.
