Fig. 1
From: A novel lipophilic amiloride derivative efficiently kills chemoresistant breast cancer cells
Modification of amiloride with lipophilic substituents enhances its cytotoxic potency. (A) Structure of amiloride with its pyrazine carbons numbered. (B–D) Structures of 2- and 5-substituted amiloride derivatives benzamil, HMA and 10357 are depicted. (E) Cytotoxic potency of amilorides toward cultured breast cancer cell lines after 24-h treatment. Data are presented as IC50 (μM) averages ± SEM.
