Table 3 MCF7 chemoresistant cells are susceptible to amiloride derivatives but not conventional chemotherapeutics.

From: A novel lipophilic amiloride derivative efficiently kills chemoresistant breast cancer cells

Cell line

TAM (mM)

DTX (mM)

DOXO (mM)

HMA (mM)

LLC1 (mM)

MCF7

–

1 ± 0.6

2 ± 0.3

27 ± 2

13 ± 2

MCF7 MX-100

–

13 ± 3

7 ± 0.5

39 ± 3

12 ± 1

MCF7 TS

13 ± 1

–

–

68 ± 3

25 ± 1

MCF7 TR-1

ND

–

–

67 ± 4

26 ± 2

MCF7 TR-5

ND

–

–

59 ± 5

19 ± 2

  1. The table depicts parent and chemoresistant MCF7 cell line derivatives titrated with chemotherapeutic agents tamoxifen (TAM), docetaxel (DTX), doxorubicin (DOXO), HMA, or LLC1 for 24 h to determine their IC50 values. ND denotes that an IC50 value could not be determined due to the very high dosage required. Data represent a minimum of three independent biological replicates and are presented as averages ± SEM.
Back to article page