Table 2 Discriminative abilities of the newly defined MoCAraw (new) and the original MoCA(+1) (original) cutoffs stratified by age and education groups.
Age | < 55 years old [22–54] (n = 65) | 55–70 years old [55–70] (n = 119) | > 70 years old [70–98] (n = 167) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Years of education | ≤ 12 (n = 24) | > 12 (n = 41) | ≤ 12 (n = 47) | > 12 (n = 72) | ≤ 12 (n = 93) | > 12 (n = 74) | ||||||
PSCI prevalence, % | 83.3 | 56.1 | 85.1 | 59.7 | 75.5 | 66.2 | ||||||
MoCA(+1) (median, IQR) | 25 (22–27) | 28 (26–28) | 23 (19.5–27) | 26 (24–27) | 22 (18–25) | 25 (22–26.8) | ||||||
MoCA cutoff | new, 26a | original, 26 | new, 28 | original, 26 | new, 26a | original, 26 | new, 26 | original, 26 | new, 22 | original, 26 | new, 25 | original, 26 |
AUC | 0.763 | 0.675 | 0.818 | 0.674 | 0.898 | 0.887 | 0.811 | 0.811 | 0.827 | 0.707 | 0.781 | 0.718 |
Sensitivity, % | 75.0 | 60.0 | 69.6 | 34.8 | 82.5 | 77.5 | 65.1 | 65.1 | 61.6 | 86.3 | 63.3 | 75.5 |
Specificity, % | 75.0 | 75.0 | 77.8 | 100.0 | 100.0 | 100.0 | 82.8 | 82.8 | 90.0 | 55.0 | 84.0 | 68.0 |
LR+ (95% CI) | 3.00 (0.54–16.69) | 2.40 (0.42–13.60) | 3.14 (1.27–7.74) | Infinite | Infinite | Infinite | 3.78 (1.65–8.63) | 3.78 (1.65–8.63) | 6.16 (1.63–23.24) | 1.92 (1.17–3.14) | 3.96 (1.57–9.95) | 2.36 (1.30–4.27) |
LR− (95% CI) | 0.33 (0.13–0.86) | 0.53 (0.24–1.16) | 0.39 (0.20–0.76) | 0.65 (0.48–0.88) | 0.18 (0.09–0.34) | 0.23 (0.13–0.40) | 0.42 (0.27–0.65) | 0.42 (0.27–0.65) | 0.43 (0.31–0.59) | 0.25 (0.12–0.50) | 0.44 (0.29–0.66) | 0.36 (0.21–0.63) |
Youden Index | 0.50 | 0.35 | 0.47 | 0.35 | 0.83 | 0.78 | 0.48 | 0.48 | 0.52 | 0.41 | 0.47 | 0.43 |
False negative rate, % | 25.0 | 40.0 | 30.4 | 65.2 | 17.5 | 22.5 | 34.9 | 34.9 | 38.4 | 13.7 | 36.7 | 24.5 |
False positive rate, % | 25.0 | 25.0 | 22.2 | 0.0 | 0.0 | 0.0 | 17.2 | 17.2 | 10.0 | 45.0 | 16.0 | 32.0 |
Accuracy, % | 75.0 | 62.5 | 73.2 | 63.4 | 85.1 | 80.9 | 72.2 | 72.2 | 67.7 | 79.6 | 70.3 | 73.0 |
