Fig. 6
From: ANGPTL4 plays a paradoxical role in gastric cancer through the LGALS7 and Hedgehog pathways
ANGPTL4 promotes growth, lymphangiogenesis, angiogenesis and metastasis in lymph nodes in a manner dependent on LGALS7 in vivo. (A) The weight and volume of xenografts of vector-MKN7, ANGPTL4 OE-MKN7, vector-AGS, and ANGPTL4 OE-AGS cells. (B) IHC staining for the expression of ANGPTL4, LGALS7, Bax, Bcl-2, CCNB1, Cdc25A, Ki-67, PCNA, Vimentin, E-cad, Shh and Gli1 in the xenografts of Vector-MKN7, ANGPTL4 OE-MKN7, Vector-AGS, and ANGPTL4 OE-AGS (a representative image is displayed at 400× magnification). (C) The volume of lymph nodes in vector-MKN7, ANGPTL4 OE-MKN7, vector-AGS, and ANGPTL4 OE-AGS cells. (D) Lyve1 and CD34 protein expression in the xenografts of vector-MKN7, ANGPTL4 OE-MKN7, vector-AGS, and ANGPTL4 OE-AGS cells in different groups. (E) ANGPTL4 expression in the lymph nodes from the xenografts of Vector-MKN7, ANGPTL4 OE-MKN7, Vector-AGS, and ANGPTL4 OE-AGS cells detected by IHC (a representative image is displayed at 400× magnification), *p<0.05, ***p<0.001 .
