Fig. 1 | Scientific Reports

Fig. 1

From: SGLT2 inhibition mitigates transition from acute kidney injury to chronic kidney disease by suppressing ferroptosis

Fig. 1

Luseogliflozin-mediated improvements in renal function and histology at 48 h post ischemia/reperfusion (I/R) injury in mice. (a–c) Serum levels of blood urea nitrogen (BUN; a, and creatinine (Cr; b), and histological findings of kidney sections stained with hematoxylin and eosin (c) at 48 h post I/R injury. (d) Acute tubular necrosis (ATN) scores in the following groups: vehicle-treated + sham-operated (n = 5), luseogliflozin-treated + sham-operated (n = 5), vehicle-treated + I/R-injured (n = 10), and luseogliflozin-treated + I/R-injured (n = 10). (e and f) Histological findings and quantification of kidney sections immunostained for kidney injury molecule 1 (KIM-1) at 48 h post I/R injury; *P < 0.05, **P < 0.01, as determined by one-way analysis of variance. n.s., not significant.

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