Table 1 Influence of formulation and process variables on the particle size, PDI, and zeta potential of various phosalosomal formulations.
Formula | Phosal Conc. (% v/v) | Homogeniz-ation time (min) | Homogenization speed (rpm) | Sonication time (min) | Surfactant type | Size (nm) | Zeta (mV) | PDI |
|---|---|---|---|---|---|---|---|---|
PHs 1 | 3 | 0 | 4200 | 5 |  | 1260 ± 11.5 | −35.5 ± 4.38 | 0.849 ± 0.133 |
PHs 2 | 3 | 10 | 4200 | 5 |  | 217.0 ± 4.67 | −33.0 ± 5.67 | 0.421 ± 3.041 |
PHs 3 | 3 | 15 | 4200 | 5 |  | 160.3 ± 7.01 | −31.3 ± 6.37 | 0.348 ± 2.450 |
PHs 4 | 3 | 30 | 4200 | 5 |  | 144.4 ± 0.46 | −6.58 ± 1.01 | 0.205 ± 0.030 |
PHs 5 | 3 | 15 | 6700 | 5 |  | 130.4 ± 1.92 | −9.76 ± 4.72 | 0.145 ± 0.011 |
PHs 6 | 3 | 15 | 12,000 | 5 |  | 156.9 ± 2.06 | −0.44 ± 7.13 | 0.135 ± 0.016 |
PHs 7 | 3 | 15 | 4200 | 15 |  | 160.9 ± 11.12 | −28.7 ± 07.58 | 0.317 ± 0.045 |
PHs 8 | 3 | 15 | 4200 | 30 |  | 169.1 ± 1.94 | −29.2 ± 12.03 | 0.284 ± 0.020 |
PHs 9 | 1.5 | 15 | 4200 | 15 |  | 199.9 ± 9.95 | −42.2 ± 4.03 | 0.507 ± 0.036 |
PHs 10 | 5 | 15 | 4200 | 15 |  | 135.0 ± 1.70 | −22.0 ± 8.65 | 0.326 ± 0.047 |
PHs 12 | 3 | 15 | 4200 | 15 | Span | 185.0 ± 2.40 | −49.1 ± 6.15 | 0.491 ± 0.001 |
PHs 13 | 3 | 15 | 4200 | 15 | Tween (Oil phase) | 133.3 ± 0.61 | −16.5 ± 3.10 | 0.297 ± 0.007 |
PHs 14 | 3 | 15 | 4200 | 15 | Tween (Aqueous phase) | 269.0 ± 24.33 | −22.1 ± 3.38 | 0.748 ± 0.065 |
PHs 15 | 3 | 15 | 4200 | 15 | Tween + poloxamer | 277.6 ± 12.15 | −15.4 ± 4.04 | 0.368 ± 0.032 |
PHs 16 | 3 | 15 | 4200 | 15 | Tween + poloxamer + SDC | 148.8 ± 5.51 | −19.2 ± 3.41 | 0.526 ± 0.082 |
PHs 17*a | 3 | 15 | 4200 | 15 | Tween (Oil phase) | 264.5 ± 8.21 | −32.6 ± 4.67 | 0.245 ± 4.86 |
PHs 18*b | 3 | 15 | 4200 | 15 | Tween (Oil phase) | 304.3 ± 3.89 | −35.1 ± 4.56 | 0.597 ± 1.06 |
