Fig. 3 | Scientific Reports

Fig. 3

From: A composite patch loaded with 2-Deoxy Glucose facilitates cardiac recovery after myocardial infarction via attenuating local inflammatory response

Fig. 3The alternative text for this image may have been generated using AI.

The employment of 2-DG patch improves cardiac function in mice post-MI. (A) Representative M-mode short-axis echocardiography images of mouse hearts on Day 0 and Day 28 post-MI. (B) Quantitative analysis of LVEF and LVFS at baseline, day 0, day 3, day 7, day 14, and day 28 post-MI (n = 8–10). * for the comparison of MI + 2-DGpatch group with MI group. (C,D) The reduction in LVEF (C) and LVFS (D) on day 7 and day 28 post-MI. (E) Representative images of Masson’s trichrome-stained heart sections on Day 28 after surgery. Scale bar, 4 mm. (F) Quantification of the scar area (n = 8–10). (G,H) Representative images (G) and quantification (H) of collagen content in the infarct border zone with Sirius red staining (red) at day 28 post-MI. Scale bar, 500 μm. n = 8–10, three independent sections per group. (I) Representative graphs of capillaries in the infarct zone detected with CD31 immunofluorescence staining (red) on Day 28 post-MI. Scale bar, 200 μm. (J) Quantitative analysis of the capillary density (n = 8–10, three independent sections per group). Data are presented as the means ± SD and were analyzed using one-way ANOVA followed by Tukey’s test. LVEF and LVFS were analyzed using two-way ANOVA followed by Tukey’s test (*p < 0.05, **p < 0.01, ***p < 0.001, and ns for not significant).

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