Fig. 4 | Scientific Reports

Fig. 4

From: A composite patch loaded with 2-Deoxy Glucose facilitates cardiac recovery after myocardial infarction via attenuating local inflammatory response

Fig. 4The alternative text for this image may have been generated using AI.

Glycolytic inhibitor-loaded patch protects against local inflammatory response in infarcted hearts. (A–D) Relative gene expression of Glut1 (A), Hk2 (B), Pfkl (C), and Pkm2 (D) in myocardium (n = 3). (E,H) Relative gene expression of Nos2 (E), Il1b (F), Il6 (G), and Tnfa (H) in myocardium (n = 3). (I,J) Representative images (I) and quantification (J) of western blotting analysis of iNOS in infarcted hearts on Day 3 post-MI (n = 3). Original blots/gels are presented in Supplementary Figure S5. (K,L) Representative images (K) and quantification (L) of superoxide levels in ischemic myocardium using DHE staining at day 3 after MI (n = 5–8). Scale bar, 200 μm. Error bars represent the SD, and significance was determined using one-way ANOVA followed by Tukey’s test (*p < 0.05, **p < 0.01, and ***p < 0.001).

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