Table 2 Adjusted hazard ratios for the protRS in the overall cohorts and stratified analyses in the COPDGene testing set, LSC, MESA, and SPIROMICS.

From: A protein risk score for all-cause and respiratory-specific mortality in non-Hispanic white and African American individuals who smoke

Stratum

COPDGene testing set (n = 550)

LSC (n-217)

MESA (n = 683)

SPIROMICS (n = 239)

HR (95% CI)

p

HR (95% CI)

p

HR (95% CI)

p

HR (95% CI)

p

Current smokers

2.3 (1.3–4.1)

0.0057

1.3 (0.74–2.3)

0.35

3.4 (0.8–15)

0.098

2 (1–3.7)

0.041

Former smokers

2.8 (1.8–4.1)

8.8E−07*

0.94 (0.58–1.6)

0.82

1.7 (1.3–2.3)

0.00011*

1.6 (0.83–3.3)

0.16

Ever smokers

2.6 (1.9–3.5)

1.60E−10*

1.1 (0.66–1.9)

0.68

2 (1.4–2.7)

8.20E-05*

1.6 (1.1–2.4)

0.026

Never smokers

NA

NA

1.3 (0.7–2.5)

0.39

1.7 (1.1–2.7)

0.013

NA

NA

COPD cases (GOLD 2–4)

2.7 (1.8–4.1)

1.70E−06*

NA

NA

1.7 (0.79–3.6)

0.17

1.2 (0.65–2.2)

0.57

Controls (GOLD 0)

2.7 (1.3–5.6)

0.0099

NA

NA

1.8 (1.2–2.5)

0.0023*

4.6 (1.8–12)

0.0016*

Overall

2.6 (1.9–3.5)

1.60E–10*

1.2 (0.81–1.8)

0.36

1.9 (1.4–2.5)

2.5E–06*

1.6 (1.1–2.4)

0.026

  1. Multivariable models were adjusted for age, sex, self-reported race, current smoking status, pack years of smoking (when available), FEV1% predicted, BMI, MMRC dyspnea score, and 6-min walk distance. GOLD = Global Initiative for Chronic Obstructive Lung Diseases. HR, hazard ratio. See Table 1 legend for other abbreviations. *, below Bonferroni threshold of 0.05/4 cohorts/5 strata = 0.0025. All included COPDGene and SPIROMICS participants are ever smokers.
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