Table 3 Subgroup analysis for the association between serum selenium concentrations and cause-specific mortality.

From: Influence of smoking status on the relationship between serum selenium and cause-specific mortality in US adults

 

N

All-cause mortality HR 95%CI, p

P for interaction

non-CVDs relative mortality HR 95%CI, p

P for interaction

Serum selenium (μg/L)

 

 ≤ 129.82

 > 129.82

 

 ≤ 129.82

 > 129.82

 

Age

   

0.104

  

0.128

 ≤ 60

3700

0.95 (0.93,0.97), < 0.001

1.01 (1.00,1.03), 0.005

 

0.95 (0.92,0.98), 0.002

1.01 (1.00,1.03), 0.063

 

 > 60

1799

0.97 (0.96,0.99), 0.002

1.00 (0.99,1.01), 0.402

 

0.98 (0.96,0.99), 0.044

1.00 (0.99,1.02), 0.355

 

Gender

   

0.320

  

0.097

Male

2793

0.96 (0.95,0.98), < 0.001

1.00 (0.99,1.01), 0.902

 

0.96 (0.94,0.98), < 0.001

1.00 (0.98,1.02), 0.978

 

Female

2706

0.97 (0.96,0.99), < 0.001

1.01 (1.00,1.01), 0.005

 

0.98 (0.96,1.01), 0.151

1.01 (1.00,1.02),0.013

 

Smoke

   

0.001

  

 < 0.001

Never smoker

2959

0.98 (0.96,1.00), 0.053

1.00 (0.99,1.01), 0.434

 

0.99 (0.96,1.01), 0.312

1.00 (0.99,1.02), 0.911

 

Former smoker

1434

0.96 (0.94,0.99), 0.001

1.00 (0.99,1.01), 0.840

 

0.97 (0.94,1.01), 0.109

1.00 (0.99, 1.01), 0.900

 

Current smoker

1106

0.96 (0.94,0.98), < 0.001

1.02 (1.02,1.03), < 0.001

 

0.96 (0.94, 0.98), < 0.001

1.02 (1.01,1.03), < 0.001

 

PIR

   

0.011

  

0.018

 ≤ 1.3

1722

0.97 (0.96,0.99), < 0.001

1.01 (0.99,1.01), 0.111

 

0.97 (0.95,1.00), 0.053

1.01 (0.99,1.02), 0.101

 

1.3–3.5

2029

0.97 (0.95,0.99), 0.006

1.00 (0.98,1.01), 0.685

 

0.97 (0.94,0.99), 0.008

0.99 (0.98,1.02), 0.611

 

 ≥ 3.5

1748

0.97 (0.95,0.99), 0.016

1.01 (0.99,1.02), 0.131

 

0.98 (0.96,1.01), 0.177

1.01 (0.99,1.02), 0.138

 

Hypertension

   

 < 0.001

  

0.464

Yes

2033

0.98 (0.96,0.99), < 0.001

1.00 (0.99,1.01), 0.108

 

0.98 (0.96,0.99), 0.041

1.00 (0.99,1.01), 0.423

 

No

3455

0.97 (0.95,0.98), < 0.001

1.00 (0.99,1.02), 0.667

 

0.97 (0.95,0.98), < 0.001

1.00 (0.99,1.02), 0.667

 

High Cholesterol

   

 < 0.001

  

 < 0.001

Yes

1995

0.97 (0.96,0.99), 0.002

1.00 (0.99,1.01), 0.401

 

1.00 (0.98,1.03), 0.880

0.99 (0.98,1.00), 0.187

 

No

3141

0.96 (0.94,0.98), < 0.001

1.01 (0.99,1.03), 0.061

 

0.95 (0.93,0.97), < 0.001

1.01 (0.99,1.03), 0.086

 

Stroke

   

0.210

  

0.024

Yes

194

0.97 (0.91,1.03), 0.260

1.01 (0.99,1.02), 0.274

 

1.01 (0.94,1.08), 0.866

1.01 (0.99,1.02), 0.170

 

No

5299

0.97 (0.96,0.98), < 0.001

1.01 (0.99,1.01), 0.078

 

0.97 (0.96,0.98), < 0.001

1.01 (0.99,1.02), 0.243

 
  1. Adjusted for age, gender, DBP, smoke, PIR, hypertension, high Cholesterol, stroke except for subgroup variables.
  2. DBP Diastolic blood pressure, SBP Systolic blood pressure, PIR Family income-to-poverty ratio, CVDs Cardiovascular diseases.
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