Fig. 3 | Scientific Reports

Fig. 3

From: Minocycline alleviates lipopolysaccharide-induced cardiotoxicity by suppressing the NLRP3/Caspase-1 signaling pathway

Fig. 3

Minocycline inhibits LPS-induced NLRP3/Caspase-1 pathway activation in mice heart. (A) Representative Western blot bands of NLRP3, Caspase-1, IL-1β, and IL-18, and (B–E) their statistical graphs. (F) An IHC staining assay was performed to detect the levels of NLRP3 and Caspase-1 in heart tissues. Data were presented as mean ± SD, n = 5–6 mice per group; ns: statistically non-significant; *P < 0.05, **P < 0.01, ***P < 0.001 vs. Control group; #P < 0.05, ##P < 0.01, ###P < 0.001 vs. LPS group.

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