Fig. 4 | Scientific Reports

Fig. 4

From: Defining the transcriptome of PIK3CA-altered cells in a human capillary malformation using single cell long-read sequencing

Fig. 4

Notch signaling is absent in PIK3CAmut populations. (a) Chord diagram showing Notch-mediated signaling between PIK3CAwt but not PIK3CAmut fibroblasts and undifferentiated keratinocytes. (b) Barplot showing the relative contribution of the JAG1-NOTCH3 versus JAG1-NOTCH1 receptor signaling to overall Notch pathway signaling. (c,d) Dotplot of the top 10 enriched Gene Ontology Biological Processes in PIK3CAwt (c) and PIK3CAmut (d) cells.

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