Table 1 Overview of the study evaluating the effects of AS-NS, Carr-NS and HPMC-NS on nasal epithelial integrity and mucociliary function.

From: Astodrimer sodium nasal spray forms a barrier to SARS-CoV-2 in vitro and preserves normal mucociliary function in human nasal epithelium

Schedule

Event

Series 1

Series 2

0 h

0 h

Start of treatment phase

3 h

NA

Addition of isoproterenol [a]

4 h

24 h

Assay (end of treatment phase) [b]

28 h

48 h

Assay (end of recovery phase) [b]

  1. [a]: Isoproterenol was added only to the Series 1 inserts, which served as positive controls for the MCC and CBF assessments. Note [b]: Assay procedures included measurement of CBF, evaluation of MCC, TEER measurement, and LDH analysis.
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