Fig. 4 | Scientific Reports

Fig. 4

From: Investigation of chimeric transcripts derived from LINE-1 and Alu retrotransposons in cerebellar tissues of individuals with autism spectrum disorder (ASD)

Fig. 4

Immunohistochemical staining of cerebellar Purkinje cells with anti-calbindin antibody in ASD and unaffected CTRL. (A) The paraffin-embedded cerebellum tissue sections were stained with anti-calbindin (DAB-positive cells) and counterstained with hematoxylin. The images were photographed at 20X and 10X, respectively. (B–E) Boxplot of Purkinje cells density (PCs/mm), Purkinje cell body size (PCs soma, mm2), molecular layer thickness (Mol layer length), molecular layer thickness at folium surface (Mol layer length; FS), respectively. (F) Correlation matrix between neuropathology in the cerebellum of ASD and genes that produced chimeric transcripts and related to developments and abnormalities of the cerebellum. (NS = not significant, * = significant at the P-value less than 0.05).

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