Fig. 7

Hom6 contributes to canonical cytoplasmic functions and to a number of diverse nuclear roles. In the budding yeast Saccharomyces cerevisiae, a series of Hom and Thr proteins have well-established cytoplasmic roles in threonine synthesis. In addition to their cytoplasmic functions, the candidates chosen for this study(*) were found to promote and maintain silencing at the rDNA. Further investigation of Hom6's nuclear roles revealed its significance in DNA repair. Along with the MRX complex, Hom6 works to repair DNA DSBs via non-homologous end joining. Although we have no evidence for a direct physical interaction, our data reveal that Hom6 catalytic activity is required for this functional relationship.