Fig. 5 | Scientific Reports

Fig. 5

From: Dissecting the novel molecular interactions of solute carrier family 4 member 4 (SLC4A4) for prostate cancer (PCa) progression

Fig. 5

SLC4A4 knockdown induces cell cycle arrest in PCa cells by increasing hypophosphorylation of retinoblastoma protein (RB1) (A) SLC4A4 knockdown decreased total RB expression and induced hypophosphorylation at serine 608 (S608) of RB. (B) Co-immunoprecipitation (Co-IP) results showed that SLC4A4 KD stable cells had diminished total RB interaction with the SLC4A4 protein (C) Cell cycle distribution analysis showed the percentage of PCa cells in G0/G1, S and G2/M. SLC4A4 knockdown induced G0/G1 cell cycle arrest in PCa cells. The results are presented as means ± standard error of three independent experiments.

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