Table 1 Baseline characteristics, ANRS COV01 INTENSE-COV.
n (%) or median [interquartile range] | LPVr N = 96 | LPVr + TLM N = 100 | LPVr + ATV N = 98 |
|---|---|---|---|
Demographics | |||
Age (years) | 36 [30–46] | 38 [32–49] | 38 [33–45] |
Men | 47 (49) | 49 (49) | 42 (43) |
Body mass index (kg/m2) | 26 [22–29] | 27 [23–30] | 25 [21–29] |
Comorbid conditions | |||
Hypertension | 5 (5) | 5 (5) | 7 (7) |
Asthma | 4 (4) | 3 (3) | 10 (10) |
Diabetes mellitus | 1 (1) | 4 (4) | 4 (4) |
Chronic heart disease | 1 (1) | 2 (2) | – |
Hepatic disease | 2 (2) | 1 (1) | |
Chronic hematologic disease | 3 (3) | – | – |
HIV | 1 (1) | – | 1 (1) |
Malignancy | 1 (1) | – | – |
Autoimmune disease | – | – | 1 (1) |
Chronic lung disease (excl. asthma) | – | – | – |
Chronic renal disease | – | – | – |
Central nervous system disease | – | – | – |
Peripheral nervous system disease | – | – | – |
COVID-19 | |||
Moderate COVID-19 | 13 (14) | 11 (11) | 12 (12) |
Age of first symptoms (days) | 5 [4–6] | 5 [4–6] | 5 [4–6] |
Number of symptoms | 5 [3–7] | 5 [4–7] | 5 [4–7] |
Oxygen delivery | 7 (7) | 6 (6) | 4 (4) |
Vital signs | |||
Respiratory rate (breath/min) | 19 [18–20] | 19 [18–20] | 19 [18–20] |
Temperature (°C) | 37 [37–37] | 37 [37–37] | 37 [37–37] |
Oximetry (%) | 98 [97–99] | 98 [97–99] | 98 [97–99] |
Heart rate (beat/min) | 78 [69–87] | 78 [70–86] | 77 [69–84] |
Laboratory results | |||
SARS-CoV2 viral load (Ct) | 27 [25–29] | 27 [25–29] | 27 [24–29] |
C-reactive protein (mg/L) | 3 [1–9] | 2 [1–11] | 3 [1–11] |
White blood cells (/mm3) | 4420 [3480–5510] | 4470 [3460–5340] | 4175 [3640–5125] |
Fibrinogen (g/L) | 2.86 [2.40–3.79] | 2.69 [2.38–3.33] | 3.12 [2.45–3.79] |
D-dimers (mg/L) | 265 [166–507] | 283 [175–408] | 417 [217–917] |
eGFR—CKD-EPI (mL/min per 1.73m2) | 113 [97–132] | 108 [86–125] | 109 [90–126] |
Drugs received | |||
Antibiotics | 85 (89) | 87 (87) | 89 (91) |
Anticoagulants | 37 (39) | 41 (41) | 36 (37) |
