Fig. 2 | Scientific Reports

Fig. 2

From: Massively parallel sequencing of mitochondrial genome in primary open angle glaucoma identifies somatically acquired mitochondrial mutations in ocular tissue

Fig. 2

A graph to show the relative mtDNA copy number of three mitochondrial genes (Cyt-B, ND1 and ND4) with normalization to a nuclear gene (PK) after qPCR testing of DNA extracted from glaucoma and control Tenon’s fibroblasts. The mitochondrial genes include ND-1: NADH dehydrogenase gene 1, ND-4: NADH dehydrogenase gene 4, Cyt-B: Cytochrome-B. These were normalized to a nuclear gene (PK: Pyruvate kinase). Two-way ANOVA testing demonstrated a significant increase in glaucoma compared to controls (p = 0.0008). qPCR- quantitative polymerase chain reaction. Legend-shaded—glaucoma, non-shaded- controls.

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