Table 3 Model inputs used to calibrate the model in 2010 and to simulate seasons, from 2011 to 2021, USA.

Season	Age class	Size of VP	Main circulating subtype ^#1	Clade of main circulating subtype ^#2	Normalized AgD between vaccine and main circulating strain ^#2
Season	Age class	Size of VP	Main circulating subtype ^#1	Clade of main circulating subtype ^#2	HA	NA
2010–2011 (calibration)	50–90	1031	H1N1	NA	0	0
2010–2011 (calibration)	50–90	1031	H3N2	NA	0.008	0.002
2011–2012	50–64	409	H3N2	3B	0.077	0
2011–2012	65–96	622	H3N2	3B	0.077	0
2012–2013	50–64	409	H3N2	3 C	0.00458	0.00702
2012–2013	65–96	622	H3N2	3 C	0.00458	0.00702
2013–2014	50–64	409	H1N1	6 C	0	0.0123
2013–2014	65–96	622	H1N1	6 C	0	0.0123
2014–2015	50–64	409	H3N2	3 C.3	0.116	0
2014–2015	65–96	622	H3N2	3 C.3	0.116	0
2015–2016	50–64	409	H1N1	6B	0	0.0141
2015–2016	65–96	622	H1N1	6B	0	0.0141
2016–2017	50–64	409	H3N2	3 C.2a	0	0.109
2016–2017	65–96	622	H3N2	3 C.2a	0	0.109
2017–2018	50–64	409	H3N2	3 C.2a1	0.0466	0.223
2017–2018	65–96	622	H3N2	3 C.2a1	0.0466	0.223
2018–2019	50–64	409	H1N1	6B.1 A.1	0.0127	0
	65–96	622	H1N1	6B.1 A.1	0.0127	0
	50–64	409	H3N2	3 C.2a2	0.15	0.0573
	65–96	622	H3N2	3 C.2a2	0.15	0.0573
2019–2020	50–64	409	H1N1	6B.1 A.5b	0.0892	0
2019–2020	65–96	622	H1N1	6B.1 A.5b	0.0892	0
2021–2022	65–96	1031	H3N2	3 C.2a.1a	0.461	0.113

^#1: CDC MMWR reports: https://www.cdc.gov/flu/season/past-flu-seasons.htm.
^#2: Nextstrain webapp⁴⁹. Consulted on the 2022/11/08; https://nextstrain.org/flu/seasonal/h3n2/ha/12y@2022-11-08. Normalization with A/Darwin/6/2021, 3 C. 2a1b.2a.2 HA: 13.1.

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