Table 4 Outputs of simulated vaccine effectiveness (sVE) against symptomatic infections in vaccine arms and weighted sVE using the proportion of vaccinees receiving split standard dose (SD) rather than split high dose (HD) over consecutive seasons.

From: Multi-strain modeling of influenza vaccine effectiveness in older adults and its dependence on antigenic distance

Season

Age class

sVE of SD arm

sVE of HD arm

% of SD/HD #1

Weighted sVE

Adjusted VE CDC all vaccine types (95% CI)#2

Season category #2

2011–2012

50–64

38

51

100

38

39 (-13, 67)

Match

65–96

32

37

87

33

42 (-37, 76)

Match

2012–2013

50–64

45

61

100

45

52 (33, 65)

Egg

65–96

34

44

78

36

11 (-41,43)

Egg

2013–2014

50–64

51

71

100

51

64 (48,74)

Match

65–96

37

49

75

40

59 (25,77)

Match

2014–2015

50–64

35

46

100

35

12 (-19, 34)

Mismatch

65–96

29

34

63

31

12 (-29, 40)

Mismatch

2015–2016

50–64

50

71

100

50

10 (-26, 36)

Match

65–96

37

49

47

43

66 (36, 81)

Match

2016–2017

50–64

45

61

100

45

40 (24, 53)

Egg

65–96

35

44

37

41

21 (-15, 45)

Egg

2017–2018

50–64

37

52

100

37

21 (-5, 41)

Egg

65–96

31

37

30

35

10 (-32, 39)

Egg

2018–2019 H1N1

50–64

51

68

100

51

30 (6, 48)

Match

65–96

35

48

26

45

16 (-41, 51)

Match

2018–2019 H2N3

50–64

36

43

100

36

-20 (-74, 18)

Mismatch

65–96

28

31

26

30

13 (-46, 48)

Mismatch

2019–2020

50–64

46

56

100

46

40 (20, 56)

Match

65–96

28

38

20

36

42 (9, 64)

Match

2021–2022

65–96

19

21

15

21

32 (-79, 74)

Mismatch

  1. #1: Net et al., 202158. #2: CDC MMWR reports, with estimates typically adjusted for study site, age, sex, underlying medical conditions, and days from illness onset to enrollment. \(WeightedsVE=sV{E_{SDarm}} \cdot \% splitSD+sV{E_{HDarm}} \cdot \left( {100 - \% splitSD} \right)\).
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