Fig. 5 | Scientific Reports

Fig. 5

From: Elevated α-1,2-mannosidase MAN1C1 in glioma stem cells and its implications for immunological changes and prognosis in glioma patients

Fig. 5

MAN1C1 expression correlates with increased immune cell infiltration in gliomas. (A–D) Correlations between (A) stromal score, (B) immune score, (C) ESTIMATE score, and (D) tumor purity and MAN1C1 expression levels; (E) A heatmap of immune responses according to TIMER, CIBERSORT, QUANTISEQ, XCELL, MCP counter, and EPIC algorithms between the high- and low-MAN1C1 groups of gliomas in the TCGA dataset; (F) Differences in immune cells and function in CIBERSORT between high- and low-MAN1C1 groups of gliomas in the TCGA dataset. (G) Differences in the Immune activity scores cancer-immunity cycle between high- and low-MAN1C1 groups of gliomas in the TCGA dataset. (H) A heatmap of gene signatures in the cancer-immunity cycle between the high- and low-MAN1C1 groups of gliomas in the TCGA dataset; (I) A heatmap of immunomodulator and chemokine-related genes between the high- and low-MAN1C1 groups of gliomas in the TCGA dataset;.

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