Fig. 6
Experimental set-up. Radiation field and dosimetry (A), timeline (B) and graphical overview (C) of the X-ray and proton experiments. In (A), the radiation field size was identical for all irradiation groups, and covered the oral cavity, pharynx, and the major salivary glands. The depth-dose curves shown (including 1-sigma uncertainty) are re-analysed alanine dosimetry data from41, including normalization and cubic spline interpolation across the mouse head. In (B), examinations of the oral cavity were performed during the early phase (days 0–35) and have been published elsewhere41. TM = transmission mode proton treatment plan, BP = Bragg peak proton treatment plan, HE = hematoxylin and eosin staining, IF = immunofluorescence labelling. Figure created with Biorender.com.
