Fig. 1
Sublingual video microscopy images taken in patients with and without sepsis. Panel A shows a video microscopy image of a patient without sepsis in our database. It shows an appropriate distribution of venules, capillaries and arterioles. Panel B shows an image from a patient included in the study with septic arthritis of the knee caused by S. aureus. It shows few recruited capillaries, poor red blood cell distribution and tissue hypoperfusion. Images published with parental permission. Panel C shows sublingual microcirculation measurement using video microscopy, software analysis of the data obtained, and PBR measurement as an indicator of glycocalyx thickness. A greater distance between the red blood cells and the endothelial wall (and therefore a greater PBR) can be seen in the damaged glycocalyx. DAMPs: damage-associated molecular patterns. PBR: perfused boundary region.
