Table 2 The results of the two-way analysis of covariance (ANCOVA) on caudate volume among patients with schizophrenia.

From: Caudate nucleus volume in medicated and unmedicated patients with early- and adult-onset schizophrenia

ANCOVA with simple main effect analysis on caudate volume

F

P-value

Partial eta2

Estimated mean caudate volumes (mm3)

EOS/AOS

0.262

0.609

0.001

  

Use of antipsychotics

11.110

< 0.001

0.034

  

EOS/AOS-by-use of antipsychotics

8.360

0.004

0.025

  

Age

0.006

0.937

0.000

  

Sex

0.609

0.436

0.002

  

Scanner

11.761

< 0.001

0.068

  

ICV

108.363

< 0.001

0.253

  

Simple main effect analysis

 

AP+

AP-

 AP+/AP- on caudate among patients with EOS

13.019

< 0.001

0.039

7939

6972

 AP+/AP- on caudate among patients with AOS

0.202

0.654

0.001

7572

7502

 

EOS

AOS

 EOS/AOS on caudate among AP + patients

11.882

< 0.001

0.036

7939

7573

 EOS/AOS on caudate among AP- patients

3.185

0.075

0.010

6972

7502

  1. There was a significant EOS/AOS-by-antipsychotic use interaction on caudate (p = 0.004) which we followed up with simple main effect analysis. Significant associations (p < 0.05) are shown in bold. For the simple main effects, statistical significance was accepted at the Bonferroni-adjusted alpha level of 0.0125. EOS: early-onset schizophrenia, AOS: adult-onset schizophrenia AP+: currently on antipsychotics, AP-: currently not on antipsychotics.
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