Fig. 2

Enriched biological processes of miR-148b-3p. (a) Gene network summarizes the miRNA targets belonging to the gene ontology (GO) term “regulation of microtubule cytoskeleton organization” as linked nodes. (b) Cell type enrichment analysis predicts the cell types regulated by miR-148b-3p. The bars indicate the transformed P-values of highly enriched cell types for each cell cluster (P-value < 0.05). (c) Chord diagram illustrates enriched biological processes of miR-148b-3p, linking each gene cluster to its corresponding processes. (d) miRNA expression levels of miR-148b-3p in patients’ samples using RT-qPCR. Error bars indicate mean ± S.D. of three independent experiments. miRNAs expressions were normalized to U6 expression. ***P < 0.001 when compared with CVS⁻. GO gene ontology, CVS⁺ blood samples with CVS, CVS⁻ blood samples without CVS.