Fig. 4

Soluble MICB regulates the activation of T cells cocultured with PANC-1. (a) IFNG mRNA expression of NKG2D^High (left) and NKG2D^Low (right) CD8 T cells cocultured with PANC-1 cells with or without ADAM inhibitor GW280264x at 10 µM. Data are mean with SEM from three independent experiments. (b) Apoptotic PANC-1 cells after coculture with NKG2D^High (left) and NKG2D^Low (right) CD8 T cells with or without ADAM inhibitor GW280264x at 10 µM. Data are mean with SEM from three independent experiments. (c) Apoptotic PANC-1 cells after coculture with NKG2D^Low CD8 T cells with or without MICB-Fc fusion protein at 200 ng/mL. Data are mean with SEM from two independent experiments.