Table 1 Copy number calling results of 15 cancer cell lines and three simulated COLO 829 cancer cell lines with different tumor cell contents.
WGS dataset | Sample name | Ploidy | WGS coverage | Informative region (Mb) | Recall (Mb) | Overall accuracy (%) |
|---|---|---|---|---|---|---|
Cell line WGS | ||||||
A2058 | 2.21 | 33.10 | 2757.71 | 2740.17 | 99.36 | |
COLO 829 T | 3.22 | 37.84 | 2768.17 | 2743.39 | 99.11 | |
HEPG2 | 2.26 | 42.04 | 2783.24 | 2776.96 | 99.77 | |
HT115 | 2.10 | 35.73 | 2759.91 | 2742.70 | 99.38 | |
KNS81 | 1.96 | 45.91 | 2761.61 | 2729.79 | 98.85 | |
LAMA84 | 3.11 | 42.52 | 2788.78 | 2777.25 | 99.59 | |
LOVO | 2.20 | 37.91 | 2760.97 | 2749.19 | 99.57 | |
LS513 | 2.28 | 31.91 | 2758.90 | 2749.62 | 99.66 | |
MKN74 | 2.30 | 42.41 | 2712.25 | 2669.85 | 98.44 | |
MM1S | 1.97 | 42.91 | 2759.18 | 2756.67 | 99.91 | |
MONO-MAC-1 | 2.09 | 38.35 | 2762.58 | 2744.30 | 99.34 | |
NCIH69 | 1.64 | 40.17 | 2717.08 | 2700.69 | 99.40 | |
OVCAR4 | 2.99 | 39.84 | 2728.81 | 2685.77 | 98.42 | |
SW1990 | 2.68 | 34.77 | 2745.19 | 2735.80 | 99.66 | |
T47D | 2.89 | 40.32 | 2766.71 | 2721.87 | 98.38 | |
Simulated cell line with normal cell contamination | ||||||
COLO 829 T 75% | N.A | 96.42 | 2754.77 | 2651.55 | 96.25 | |
COLO 829 T 50% | N.A | 95.87 | 2747.81 | 2455.02 | 89.34 | |
COLO 829 T 25% | N.A | 91.49 | 2779.28 | 1726.19 | 62.11 |