Table 2 Simple and multiple logistic regression analyses of factors associated with the development of cholestasis.

From: Presence of cholestasis and its impact on survival in SARS-CoV-2 associated acute respiratory distress syndrome

Parameter

Simple

Multiple

OR (95%CI)

P

OR (95%CI)

P

ECMO

6.670 (3.741–12.215)

< 0.001

3.094 (1.366–7.140)

0.007

ICU LOS

1.045 (1.031–1.062)

< 0.001

1.042 (1.018–1.070)

0.001

Cumulative Days Norepinephrine

1.059 (1.037–1.086)

< 0.001

0.945 (0.900–0.990)

0.019

Cumulative Days of ketamine

1.134 (1.091–1.184)

< 0.001

1.103 (1.043–1.171)

0.001

Cumulative Days of NMB

1.107 (1.039–1.188)

0.003

  

Cumulative Days of PN

1.080 (1.041–1.126)

< 0.001

  

Cumulative Days of IMV

1.050 (1.034–1.068)

< 0.001

  

Peak CRP

1.065 (1.036–1.097)

< 0.001

  

Peak IL-6*

1.596 (1.322–1.959)

< 0.001

1.411 (1.085–1.861)

0.012

Peak PCT*

1.507 (1.251–1.837)

< 0.001

  

P/F ratio nadir

0.985 (0.972–0.996)

0.013

  

Prone position

1.982 (1.041–3.847)

0.039

0.472 (0.162–1.321)

0.159

SOFA Score

1.084 (0.975–1.211)

0.141

1.228 (1.048–1.457)

0.014

  1. OR, odds ratio; CI, confidence interval; ECMO, extracorporeal membrane oxygenation; ICU, intensive care unit; LOS, length of stay; PN, parenteral nutrition; IMV, invasive mechanical ventilation; CRP, C-reactive protein; IL-6, interleukin-6; NMB, neuromuscular blockade; PCT, procalcitonin; P/F ratio, PaO2/FiO2 ratio; SOFA, Sequential Organ Failure Assessment Score.
  2. *logarithmized.
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