Fig. 7 | Scientific Reports

Fig. 7

From: Molecular identification of hyaluronate lyase, not hyaluronidase, as an intrinsic hyaluronan-degrading enzyme in Clostridium perfringens strain ATCC 13124

Fig. 7

C. perfringens strain ATCC 13124 model for degradation, import, and metabolism of hyaluronan. HysA (CPF_0394) degrades HA to unsaturated HA disaccharides on the cell surface. PTS (CPF_0401—0404) in the cytoplasmic membrane imports unsaturated HA disaccharide into the cytoplasm through phosphorylation. In the cytoplasm, UGL (CPF_0400) degrades unsaturated HA disaccharides to unsaturated uronic acid and phosphorylated amino sugar. DHU, nonenzymatically converted from unsaturated uronic acid, is metabolized by KduI (CPF_0395 and CPF_0399) and KduD (CPF_0396). The resultant is finally metabolized into glycolysis.

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