Table 2 County-level age-adjusted premature cardiovascular mortality rates (per 100,000 residents) associated with cardio-kidney-metabolic syndrome according to the social deprivation index in the US (2010–2019).

All US counties (n = 3,101)

60.7 (45.5, 82.3)

44.7 (36.2–54.9)

60.8 (48.8–76.9)

< 0.01

77.3 (61.4–93.9)

< 0.01

88.7 (70.0–110.4)

< 0.01

All US counties; only men

84.9 (64.0, 91.2)

62.7 (51.4, 77.6)

84.9 (68.7–105.3)

< 0.01

106.0 (84.2–127.4)

< 0.01

120.1 (93.8–149.0)

< 0.01

All US counties; only women

40.7 (28.1, 57.6)

26.4 (20.6, 34.1)

39.1 (29.7–51.8)

< 0.01

50.6 (39.9–64.9)

< 0.01

61.4 (44.6–76.1)

< 0.01

Only metropolitan counties

54.3 (40.2, 72.1)

41.7 (33.9, 52.2)

56.6 (44.8–71.8)

< 0.01

69.8 (55.1–85.3)

< 0.01

75.3 (57.1–92.9)

0.02

Only non-metropolitan counties

66.3 (49.0, 89.5)

47.1 (38.6, 56.5)

64.5 (52.1–82.2)

< 0.01

81.6 (66.0–98.7)

< 0.01

97.7 (76.2–115.9)

< 0.01

All US counties; non-Hispanic white residents

58.8 (44.2, 78.0)

44.3 (35.9, 54.6)

60.4 (47.3–77.2)

< 0.01

74.4 (58.3–92.5)

< 0.01

77.1 (61.3–94.4)

0.09

All US counties; non-Hispanic black residents

110.1 (85.6, 136.5)

71.9 (56.7, 89.8)

97.9 (81.1–119.0)

< 0.01

116.9 (98.3–142.3)

< 0.01

127.8 (105.7–148.2)

< 0.01