Table 3 Coordinates of ROC for serum uric acid to discriminate patients with MMA with abnormal brain images.
Imaging findings | AUC (95% CI) | p-value | Cutoff values | Sensitivity, % | Specificity, % | PPV, % | NPV, % |
|---|---|---|---|---|---|---|---|
All imaging abnormality | 0.74 (0.66–0.81) | < 0.001 | 240.45 | 60.6 | 76.8 | 88.2 | 40.6 |
Ventricular dilation | 0.75 (0.67–0.84) | < 0.001 | 240.45 | 65.9 | 76.8 | 80.6 | 60.6 |
Myelination delay | 0.70 (0.61–0.79) | < 0.001 | 237.75 | 60.3 | 75 | 75.9 | 61.4 |
Subcortical white matter abnormality | 0.69 (0.60–0.78) | < 0.001 | 253.9 | 50.8 | 82.1 | 78 | 60.3 |
Cerebral atrophy | 0.75 (0.66–0.84) | < 0.001 | 197.7 | 84.9 | 55.4 | 64.3 | 79.5 |
Basal ganglia changes | 0.91 (0.84–0.97) | < 0.001 | 256.65 | 89.5 | 82.1 | 77.3 | 92 |
Globus pallidus changes | 0.93 (0.87–0.98) | < 0.001 | 256.65 | 92.9 | 82.1 | 72.2 | 95.8 |
Hydrocephalus | 0.77 (0.67–0.87) | < 0.001 | 240.7 | 68.6 | 76.8 | 64.9 | 83.3 |
Periventricular white matter abnormality | 0.66 (0.52–0.79) | 0.031 | 243.05 | 56.5 | 76.8 | 43.5 | 76.8 |
Thinning of the corpus callosum | 0.65 (0.43–0.86) | 0.243 | 244.4 | 66.7 | 76.8 | 23.5 | 95.6 |
