Figure 3 | Scientific Reports

Figure 3

From: A single dose of glycogen phosphorylase inhibitor improves cognitive functions of aged mice and affects the concentrations of metabolites in the brain

Figure 3

Age-related metabolomic profiles and brain region-specific responses to BAY treatment. (a) Principal component analysis (PCA) biplots of principal component 1 and principal component 2 including loadings (identified metabolites were selected for quantification of relative integrals (see Table S1) for the hippocampus (gray ellipse), cortex (yellow ellipse), and cerebellum (blue ellipse) enclosing metabolic profiles of four animal groups: young controls (Y-CTR, diamonds); young BAY-treated (Y-BAY, triangles); old controls (O-CTR, circles); and old BAY-treated (O-BAY, squares). (b-d) Circular graphs reveal the relative integral contribution of all identified metabolites that were significantly or not significantly changed during aging and/or after BAY treatment, across analyzed brain subregions, in order: (b) hippocampus, (c) cortex, and (d) cerebellum. All identified metabolites in the study significantly increased or decreased are available in the supplementary materials (Table S2).

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