Fig. 4

Volcano plots for the pairwise comparisons. (A) Number of significantly regulated proteins for each of the pairwise comparisons given as Nadjust-p-value (Nregular-p-value). (B) IDC/Crib versus non-IDC/non-Crib, (C) crib versus non-IDC/non-Crib, (D) cribriform and IDC versus non-IDC/non-Crib, and (E) IDC versus non-IDC/ non-Crib. (F) Crib versus IDC. Red horizontal line indicates 0.05 P value thresholds. Red vertical lines indicate two-fold differential regulation. The number of regulated proteins indicated in the titles is based on P values and adjusted P value with an effect size greater than twofold.