Fig. 9

The effect of lemmokaramine (1) on MCM DLN NRF-2 Luc cells. MCM DLN NRF2 Luc cells (seeded at 20,000 cells/well) were treated 24 h after seeding with 3 µM lemmokaramine (non-toxic concentration) or DMSO only and 0.25 mM H2O2. After 6 h, viability and luminescence were determined and normalized to non-treated (NT) cells, resulting in relative luminescence units (RLU). The graphs show the mean of the 3 observations and the corresponding SD. For controls, the significance of H2O2 treatment on RLU is shown. Significance is shown as p-values; **** = p < 0.0001 and ns = not significant.