Table 3 Threshold effect analysis examining the relationship between inflammatory markers and BTMs.

From: Divergent associations of inflammatory markers with bone turnover markers in elderly patients with osteoporotic fractures

 

NLR, Model 3a

MLR, Model 3b

PLR, Model 3c

PINP

β (95% CI)

P-value

β-CTX

β (95% CI)

P-value

PINP

β (95% CI)

P-value

β-CTX

β (95% CI)

P-value

PINP

β (95% CI)

P-value

β-CTX

β (95% CI)

P-value

Model Ad

One line slope

-1.1788 (-1.7230, -0.6345)

< 0.0001

-0.0104 (-0.0145, -0.0062)

< 0.0001

-17.4523 (-27.7335, -7.1710)

0.0009

-0.1327 (-0.2211, -0.0443)

0.0034

0.0326 (0.0007, 0.0645)

0.0458

0.0003 (0.0001, 0.0006)

0.0204

Model Be

Turning point (K)

6

 

7.1625

 

0.1364

 

0.8226

 

244.2857

 

311.6667

 

< K

-5.6203 (-7.3378, -3.9028)

< 0.0001

-0.0336 (-0.0442, -0.0230)

< 0.0001

202.4161 (20.1683, 384.6639)

0.0299

-0.2185 (-0.3415, -0.0954)

0.0005

0.0470 (-0.0059, 0.1000)

0.0823

0.0002 (-0.0001, 0.0006)

0.2229

> K

0.1640 (-0.5633, 0.8912)

0.6587

0.0001 (-0.0059, 0.0062)

0.9640

-20.5459 (-31.1007, -9.9910)

0.0002

0.0472 (-0.1533, 0.2477)

0.6446

0.0141 (-0.0488, 0.0769)

0.6615

0.0005 (-0.0002, 0.0013)

0.1478

Slope 2-Slope 1

5.7843 (3.6585, 7.9101)

< 0.0001

0.0338 (0.0195, 0.0480)

< 0.0001

-222.9620 (-407.4822, -38.4418)

0.0182

0.2657 (-0.0002, 0.5315)

0.0506

-0.0330 (-0.1294, 0.0634)

0.5029

0.0003 (-0.0007, 0.0013)

0.5282

LRTf

< 0.001

< 0.001

0.017

0.048

0.495

0.521

  1. NLR, neutrophil-to-lymphocyte ratio; MLR, monocyte-to-lymphocyte ratio; PLR, plateletto-lymphocyte ratio; P1NP, procollagen type 1 N-terminal propeptide; β-CTX, β-C-terminal telopeptide of type I collagen; CI, confidence interval; BMI, body mass index; Ca, calcium; UA, uric acid; CR, creatinine; AST, aspartate aminotransferase; UN, urea nitrogen; HDL, high density lipoprotein; LDL, low density lipoprotein; K, potassium; Mg, magnesium; Na, sodium; P, phosphorus; Apo A, apolipoprotein A; ALT, alanine aminotransferase; ASA, the score of american society of anesthesiologists.
  2. aAdjusted for age, sex, BMI, smoking, drinking, Ca, UA, CR, AST and Monocyte.
  3. bAdjusted for age, sex, BMI, smoking, drinking, Ca, UA, UN, CR, HDL and LDL.
  4. cAdjusted for age, sex, BMI, smoking, drinking, K, Mg, Na, P, Fibrinogen, Neutrophil, Apo A, HDL, Homocysteine, ALT and ASA.
  5. dLinear analysis, P-value < 0.05 indicates a linear relationship.
  6. eNonlinear analysis.
  7. fP-value < 0.05 means Model B is significantly different from Model A, which indicates a nonlinear relationship.
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