Fig. 3 | Scientific Reports

Fig. 3

From: Maternal e-cigarette exposure alters DNA methylome, site-specific CpG and CH methylation, and transcriptomic signatures in the neonatal brain

Fig. 3

Differential CH methylation landscape in control and e-cigarettes (e-cig) exposed neonatal brains. (a) Distribution of methylation levels of 4.92 million (in male) and 4.63 million (female) CH sites. Methylation levels range between 0 (unmethylated) to 1 (methylated). Methylation values between 0 to 1 are grouped into 5 bins. Most CH sites are unmethylated. (b) Zoomed view shows the top 1% of CH methylation levels. Zoomed view shows about 0.02% of CH sites are methylated. (c) Distribution of differentially methylated CH sites based on genomic regions in male and female offspring. (d-e) Heatmaps show the methylation levels of differentially methylated CHs on male (d) and female (e) offspring. (f-g) Enriched gene ontology (biological processes) associated with differentially methylated CHs overlapping genes in male (f) and female (g) offspring.

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